Ramsia Geisler, Martin Cramer Pedersen, Natalie Preisig, Yvonne Hannappel, Sylvain Prévost, Rajeev Dattani, Lise Arleth, Thomas Hellweg.Journal of Computational Biophysics and Chemistry 2021, 20 Geographical, Molecular, and Computational Analysis of Migraine-Causing Genes. Muhammad Naveed, Bakhtawar Bukhari, Nadia Afzal, Haleema Sadia, Bisma Meer, Tanzeela Riaz, Urooj Ali, Naveed Ahmed.Liposomes as biomembrane models: Biophysical techniques for drug-membrane interaction studies.
Hypoglycemic and Anti-Inflammatory Effects of Triterpene Glycoside Fractions from Aeculus hippocastanum Seeds.
The presence of the saponin and the drug become visible on different length scales, i.e., ranging from a global structural change to inner-membrane interactions. We found that these two additives, aescin and ibuprofen, alter the temperature-dependent structural appearance of the DMPC membrane depending on the aescin and drug content. The methods of choice are differential scanning calorimetry (DSC), and additionally wide-angle (WAXS) and small-angle X-ray scattering (SAXS). It is shown how the interaction of both substances, separately or together, alters the thermotropic phase behavior of the 1,2-dimyristoyl- sn-glycero-3-phosphocholine (DMPC) bilayer in the presence of different amounts of aescin, ranging from 20 μM to 1 mM. These amounts are higher than those usually used for medication (10–300 μM) to show possible structures and formulations for orally absorbed drug delivery systems. In the present work, we study the interaction of the saponin aescin with the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen at concentrations of 1.2–2.5 mM.